Matsumoto K, Yoshizawa N, Hatano M
Nephron. 1978;21(4):192-200. doi: 10.1159/000181393.
Using the macrophage migration inhibition test (MIT), a total of 113 patients with various renal diseases, namely glomerulonephritis (GN), were studied for evidence of cell-mediated immunity to various soluble antigens prepared. The positive rate of MIT in the presence of streptococcal antigen, glomerular basement membrane antigen, renal tubular epithelial antigen and heat-aggregated IgG antigen was 15, 23, 16 and 15%, respectively. Out of 15 positive patients who were able to be evaluated with those four antigens, 9 cases exhibited cellular hypersensitivity to two or more antigens at the same time. These findings suggest that there is an abnormal cellular response to certain antigen or widespread cell-mediated hypersensitivity to a variety of antigens in certain forms of human GN.
利用巨噬细胞移动抑制试验（MIT），对总共113例患有各种肾脏疾病（即肾小球肾炎，GN）的患者进行了研究，以寻找针对所制备的各种可溶性抗原的细胞介导免疫的证据。在存在链球菌抗原、肾小球基底膜抗原、肾小管上皮抗原和热聚集IgG抗原的情况下，MIT的阳性率分别为15%、23%、16%和15%。在能够用这四种抗原进行评估的15例阳性患者中，有9例同时对两种或更多种抗原表现出细胞超敏反应。这些发现表明，在某些形式的人类GN中，存在对某些抗原的异常细胞反应或对多种抗原的广泛细胞介导超敏反应。
