Droz B
Nouv Presse Med. 1982 Apr 8;11(16):1193-200.
In peripheral nerves, the use of radioisotopes or enzyme markers makes it possible to study the traffic of molecules and cell organelles, which flow along the axons in both directions. Such axonal transports ensure the renewal of most macromolecular components in the axons and hence contribute to maintain healthy peripheral nerve fibers. A lasting alteration of the mechanisms, which sustain transport or distribution of axonal constituents, could therefore initiate or reinforce pathological processes responsible for various human axonopathies. Investigation of axonal transport in genetic or toxic neuropathies in animals drows attention to the key-role played by neuronal dynamics in pathogenesis of nerve lesions.
在周围神经中，使用放射性同位素或酶标记物能够研究分子和细胞器的运输情况，这些分子和细胞器沿轴突双向流动。这种轴突运输确保了轴突中大多数大分子成分的更新，从而有助于维持健康的周围神经纤维。因此，维持轴突成分运输或分布的机制发生持久改变，可能引发或加强导致各种人类轴索性神经病的病理过程。对动物遗传或中毒性神经病中轴突运输的研究，使人们关注神经元动力学在神经损伤发病机制中所起的关键作用。
