Fjellner B, Hägermark O
Acta Derm Venereol. 1982;62(2):137-40.
The itch and flare responses induced by intradermal injection of histamine and the histamine liberator compound 48/80 were studied in healthy volunteers before and after exposure to UVB, UVA or PUVA administered 2-3 times weekly for 4 weeks. All three modalities were found to inhibit the responses induced by compound 48/80. The degree of tanning was most pronounced after PUVA and weakest after UVB, without any correlation between tanning and inhibition of itch. In contrast, when induced by histamine, the responses were not inhibited to the same extent, pronounced and significant inhibition being observed only for itching in subjects exposed to UVB. It is concluded that UVB, UVA and PUVA all might be of benefit in treating pruritic states if histamine release is involved and that UVB might have an additional effect by inducing hyposensitivity to itching stimuli.
在健康志愿者中，研究了每周2 - 3次、共4周给予中波紫外线（UVB）、长波紫外线（UVA）或补骨脂素加紫外线A（PUVA）照射前后，皮内注射组胺和组胺释放剂化合物48/80所诱发的瘙痒和潮红反应。发现所有这三种照射方式均能抑制化合物48/80诱发的反应。补骨脂素加紫外线A照射后晒黑程度最明显，中波紫外线照射后最弱，晒黑程度与瘙痒抑制之间无任何相关性。相比之下，由组胺诱发的反应未受到同等程度的抑制，仅在接受中波紫外线照射的受试者中观察到瘙痒有明显且显著的抑制。得出的结论是，如果涉及组胺释放，中波紫外线、长波紫外线和补骨脂素加紫外线A在治疗瘙痒状态时可能都有益处，并且中波紫外线可能通过诱导对瘙痒刺激的低敏反应而具有额外作用。
