Juhlin L, Edqvist L E, Ekman L G, Ljunghall K, Olsson M
Acta Derm Venereol. 1982;62(3):211-4.
Blood glutathione-peroxidase (GSH-Px) was determined in 61 healthy subjects and 506 patients with various skin disorders. Depressed levels were observed in patients with psoriasis, eczema, atopic dermatitis, vasculitis, mycosis fungoides and dermatitis herpetiformis. Low values of GSH-Px were also found in some patients with pemphigoid, acne conglobata, polymyositis, rheumatoid arthritis, scleroderma and systemic lupus erythematodes. Vegetarian diet, malnutrition and alcohol abuse could possibly account for the low values in some patients. Fifty patients with low GSH-Px levels were treated with tablets containing 0.2 mg selenium as Na2SeO3 and 10 mg tocopheryl succinate. The GSH-Px levels increased slowly within 6-8 weeks of treatment. The clinical effect was encouraging and calls for controlled studies.
对61名健康受试者和506名患有各种皮肤病的患者进行了血液谷胱甘肽过氧化物酶（GSH-Px）测定。在银屑病、湿疹、特应性皮炎、血管炎、蕈样肉芽肿和疱疹样皮炎患者中观察到该酶水平降低。在一些类天疱疮、聚合性痤疮、多发性肌炎、类风湿性关节炎、硬皮病和系统性红斑狼疮患者中也发现GSH-Px值较低。素食、营养不良和酗酒可能是一些患者该值较低的原因。对50名GSH-Px水平较低的患者使用含0.2毫克亚硒酸钠形式的硒和10毫克琥珀酸生育酚的片剂进行治疗。治疗6-8周内，GSH-Px水平缓慢上升。临床效果令人鼓舞，需要进行对照研究。
