Michaëlsson G, Edqvist L E
Acta Derm Venereol. 1984;64(1):9-14.
The glutathione-peroxidase (GSH-Px) activity in erythrocytes was determined in 42 men with severe acne and 47 women with acne--26 of a moderate degree and 21 severe. The male acne patients had significantly lower GSH-Px levels than the controls. The women with acne did not differ significantly from the controls in this respect when patients and controls using oral contraceptives were excluded. Both the female controls and the women with acne using oral contraceptives had significantly higher GSH-Px values than the corresponding groups not using the pill. The pubertal acne girls had the same high GHSH-Px activity as women on oral contraceptives. In an open trial 29 patients were given 0.2 mg of selenium (as Na2Se O3) + 10 mg of tocopheryl succinate for their acne twice daily for 6-12 weeks. A good result was obtained, especially in patients with pustular acne and low GSH-Px activity, and the beneficial effect was usually paralleled by a slow rise of the GSH-Px activity. Some 6-8 weeks after withdrawal of the treatment the GSH-Px values had returned to the pretreatment levels.
对42名重度痤疮男性患者和47名痤疮女性患者（26名中度痤疮患者和21名重度痤疮患者）的红细胞中谷胱甘肽过氧化物酶（GSH-Px）活性进行了测定。男性痤疮患者的GSH-Px水平显著低于对照组。排除使用口服避孕药的患者和对照组后，痤疮女性患者在这方面与对照组无显著差异。使用口服避孕药的女性对照组和痤疮女性患者的GSH-Px值均显著高于未使用避孕药的相应组。青春期痤疮女孩的GSH-Px活性与口服避孕药的女性相同。在一项开放试验中，29名患者每天两次服用0.2毫克硒（以Na2SeO3形式）+ 10毫克生育酚琥珀酸酯治疗痤疮，持续6至12周。取得了良好的效果，尤其是脓疱型痤疮且GSH-Px活性较低的患者，有益效果通常伴随着GSH-Px活性的缓慢上升。治疗停药约6至8周后，GSH-Px值恢复到治疗前水平。
