May C D, Remigio L
Clin Allergy. 1982 May;12(3):229-41. doi: 10.1111/j.1365-2222.1982.tb02523.x.
Clinical and laboratory observations are provided on high, spontaneous, in vitro histamine release (HSHR) from leucocytes (basophils), meaning without addition of antigen or other inducers of histamine release. HSHR has been observed predominantly in persons with a high degree of reaginic sensitivity to food; the leucocytes of forty-eight of fifty-eight individuals (83%), who had positive reactions to foods in double-blind challenges, exhibited HSHR. HSHR resembles antigenic release in a wide variety of characteristics. HSHR does not occur in vivo but only in vitro after compaction of leucocytes by centrifugation at room temperature. An indispensable requirement for HSHR to occur appears to be a high degree of reaginic sensitization.
提供了关于白细胞（嗜碱性粒细胞）高水平、自发性、体外组胺释放（HSHR）的临床和实验室观察结果，即不添加抗原或其他组胺释放诱导剂的情况下的组胺释放。HSHR主要在对食物具有高度反应素敏感性的人群中观察到；在双盲激发试验中对食物有阳性反应的58人中，有48人（83%）的白细胞表现出HSHR。HSHR在许多特征上类似于抗原性释放。HSHR不在体内发生，而是在室温下通过离心使白细胞浓缩后仅在体外发生。HSHR发生的一个必不可少的条件似乎是高度的反应素致敏。
