表皮生长因子对大鼠胰腺和胃十二指肠黏膜的营养作用。
Trophic action of epidermal growth factor on the pancreas and gastroduodenal mucosa in rats.
作者信息
Dembiński A, Gregory H, Konturek S J, Polański M
出版信息
J Physiol. 1982 Apr;325:35-42. doi: 10.1113/jphysiol.1982.sp014133.
Abstract
- Epidermal growth factor (EGF) infused subcutaneously in a dose of 10 micrograms/kg . h but not 1 microgram/kg . h inhibited spontaneous gastric acid and pepsin secretion, whereas when given intragastrically in a dose of 10 micrograms/kg . h it failed to affect this secretion. 2. EGF injected intraperitoneally at 8 h intervals for 24 h significantly stimulated DNA synthesis in the gastroduodenal mucosa and the pancreas, whereas when administered intragastrically it stimulated DNA synthesis only in the gastroduodenal mucosa but not in the pancreas. 3. Chronic parenteral administration of EGF significantly increased the DNA and RNA contents of the gastroduodenal mucosa and the pancreas. 4. This study demonstrates that parenteral EGF is a potent inhibitor of gastric secretion and trophic agent for the gastroduodenal mucosa and pancreas, and that the gastric inhibitory and trophic effects of EGF are the results of two separate mechanisms.
摘要
- 以10微克/千克·小时而非1微克/千克·小时的剂量皮下注入表皮生长因子（EGF）可抑制胃酸和胃蛋白酶的自发分泌，而以10微克/千克·小时的剂量胃内给药时则未能影响这种分泌。2. 每隔8小时腹腔注射EGF，持续24小时，可显著刺激胃十二指肠黏膜和胰腺中的DNA合成，而胃内给药时仅刺激胃十二指肠黏膜中的DNA合成，对胰腺无此作用。3. 长期胃肠外给予EGF可显著增加胃十二指肠黏膜和胰腺的DNA及RNA含量。4. 本研究表明，胃肠外给予的EGF是胃酸分泌的强效抑制剂及胃十二指肠黏膜和胰腺的营养因子，且EGF的胃抑制作用和营养作用是两种独立机制的结果。
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