Burrows R B, Davison P F
Mech Ageing Dev. 1982 May;19(1):85-94. doi: 10.1016/0047-6374(82)90053-7.
The degradation of pulse-labeled protein was measured in cultures of hepatocytes derived from mice of 3--4, 15--16, and 28 months of age. The rates of protein degradation were determined in culture media with varying amino acid, insulin, and glucagon concentrations. No differences with age were seen. Also no difference with age was detected in the lysosomal degradation of 125I-labeled asialofetuin.
在来自3 - 4个月、15 - 16个月和28个月龄小鼠的肝细胞培养物中，测定了脉冲标记蛋白质的降解情况。在含有不同氨基酸、胰岛素和胰高血糖素浓度的培养基中测定蛋白质降解率。未发现与年龄有关的差异。在125I标记的去唾液酸胎球蛋白的溶酶体降解中也未检测到与年龄有关的差异。
