Grinde B, Seglen P O
Hoppe Seylers Z Physiol Chem. 1981 May;362(5):549-56. doi: 10.1515/bchm2.1981.362.1.549.
Colchicine and vinblastine, two well known inhibitors of microtubular function, inhibited endogenous protein degradation as well as protein secretion and the degradation of an exogenous, internalized protein (asialo fetuin), in isolated rat hepatocytes. The inhibitors appeared to selectively affect the lysosomal pathway of degradation, since their effects were not additive to that of ammonia, a lysosomotropic degradation inhibitor.
秋水仙碱和长春碱这两种著名的微管功能抑制剂，在分离的大鼠肝细胞中，抑制内源性蛋白质降解以及蛋白质分泌和一种外源性内化蛋白质（去唾液酸胎球蛋白）的降解。这些抑制剂似乎选择性地影响溶酶体降解途径，因为它们的作用与溶酶体促降解抑制剂氨的作用并非相加关系。
