Hayakawa T, Noda A, Kondo T
Am J Gastroenterol. 1982 Sep;77(9):625-9.
To elucidate the injurious effects of alcohol on the human pancreas, serum pancreatic enzymes were followed for the first 2 months of abstinence in 31 asymptomatic alcoholics. Sequential declines of serum enzymes were observed in immunoreactive human pancreatic elastase 1 and trypsin (IRE and IRT) as well as gamma-glutamyl transpeptidase (gamma-GTP), creatine phosphokinase (CPK) and glutamate-oxaloacetate transaminase (GOT) during the abstinence. The incidence of abnormally high enzyme activities found initially changed by the end of 2 months of abstinence as follows: from 55 to 6% for IRE, from 25 to 0% for IRT, from 3 to 6% for amylase, from 76 to 22% for gamma-GTP, from 69 to 39% for CPK, from 55 to 12% for GOT, and from 38 to 12% for GPT, respectively. The decline suggests that excessive intake of alcohol enhances the escape of the enzymes from the pancreas into the serum, probably altering membrane permeability or cellular metabolism of the pancreas, a direct toxic effect of alcohol.
为阐明酒精对人体胰腺的损伤作用，对31例无症状酒精成瘾者在戒酒的前2个月跟踪检测血清胰腺酶。在戒酒期间，观察到免疫反应性人胰腺弹性蛋白酶1和胰蛋白酶（IRE和IRT）以及γ-谷氨酰转肽酶（γ-GTP）、肌酸磷酸激酶（CPK）和谷氨酸草酰乙酸转氨酶（GOT）的血清酶呈连续下降。最初发现的酶活性异常高的发生率在戒酒2个月末发生了如下变化：IRE从55%降至6%，IRT从25%降至0%，淀粉酶从3%降至6%，γ-GTP从76%降至22%，CPK从69%降至39%，GOT从55%降至12%，GPT从38%降至12%。这种下降表明，过量摄入酒精会增强酶从胰腺进入血清的逸出，可能改变胰腺的膜通透性或细胞代谢，这是酒精的直接毒性作用。
