Thomas G
Eur J Pharmacol. 1982 Jun 16;81(1):35-42. doi: 10.1016/0014-2999(82)90598-2.
Calcium ionophore A23187 produced a dose-dependent increase in plasma protein leakage on intradermal injection in rats. Studies with mepyramine and cyproheptadine indicated that histamine and 5-hydroxytryptamine (5-HT) partially contribute to the ionophore action and experiments with compound 48/80 supported these findings. Depletion of plasma kininogen levels with cellulose sulphate administered indomethacin inhibited the ionophore response in a dose-dependent manner. The inhibition was not reversed by intradermally injected prostaglandin E2 (PGE2) in doses up to 50 ng/site, suggesting that PGE2 also may not be an important mediator. It is proposed that the ionophore produces plasma protein leakage by an indirect (through histamine and 5-HT release) and a direct action on vascular endothelial cells and that indomethacin antagonises both actions by inhibiting calcium transport processes.
钙离子载体A23187在大鼠皮内注射时可引起剂量依赖性的血浆蛋白渗漏增加。用美吡拉敏和赛庚啶进行的研究表明，组胺和5-羟色胺（5-HT）部分介导了离子载体的作用，用化合物48/80进行的实验支持了这些发现。用硫酸纤维素给予消炎痛使血浆激肽原水平降低，以剂量依赖性方式抑制了离子载体反应。皮内注射高达50 ng/部位的前列腺素E2（PGE2）不能逆转这种抑制作用，提示PGE2可能也不是重要的介质。有人提出，离子载体通过间接作用（通过组胺和5-HT释放）以及对血管内皮细胞的直接作用导致血浆蛋白渗漏，而消炎痛通过抑制钙转运过程拮抗这两种作用。
