Sandler S G, Nusbacher J
Haematologia (Budap). 1982;15(1):57-69.
The increasing use of normal donors for leukapheresis to provide granulocyte concentrates requires careful monitoring of recruitment and operational procedures to minimize donor health risks. Of 18,288 leuka- and leukaplateletphereses performed in American Red Cross regional blood services during a 12-month period, only 0.27% were discontinued because of acute donor reactions. None of these reactions had serious or long-term consequences for the donors. The potential toxicities of corticosteroids and hydroxyethyl starch, and the theoretical hazards of lymphocyte depletion, raise unanswerable questions concerning long-term safety, although no serious adverse reactions related to these factors have been observed. Critical factors for leukapheresis donor safety are: selective donor recruitment, adherence to operational protocols, and continuous and informed interest of physicians responsible for pheresis programs. Additional data are needed to assess the effects of repeated leukapheresis on donors and to establish rational guidelines for donor recruitment.
越来越多地使用正常供体进行白细胞单采以提供粒细胞浓缩物，这就需要仔细监测招募过程和操作程序，以将供体健康风险降至最低。在美国红十字会地区血液服务机构12个月期间进行的18288次白细胞单采和白细胞血小板单采中，仅有0.27%因供体急性反应而中断。这些反应均未对供体造成严重或长期后果。皮质类固醇和羟乙基淀粉的潜在毒性以及淋巴细胞清除的理论风险，引发了关于长期安全性的无法回答的问题，尽管尚未观察到与这些因素相关的严重不良反应。白细胞单采供体安全的关键因素包括：选择性供体招募、遵守操作规范以及负责单采程序的医生持续且充分了解情况的关注。需要更多数据来评估重复白细胞单采对供体的影响，并制定合理的供体招募指南。
