Cameron E
Int J Vitam Nutr Res Suppl. 1982;23:115-27.
The outcome of every cancer illness is determined to a significant extent by the inherent resistance of the individual patient to his or her disease. There is increasing recognition that resistance to cancer depends, to a certain extent, upon the availability of certain nutritional factors, of which ascorbic acid appears to be the most important. Ascorbic acid protects against the destructive effects of malignant invasiveness by stabilizing the ground substance and enhancing collagen encapsulation. It is also involved in the mechanisms of both cell-mediated and humoral immunity including the production of interferon, and other factors either known or thought to be involved collectively in host resistance to neoplasia. There is also some recent evidence suggesting that ascorbate exerts a selective cytotoxic effect against malignant cells. All these observations indicate that supplemental ascorbate should be of some therapeutic value in the treatment of cancer. Clinical trials conducted over the last decade are briefly reviewed, and the balance of evidence supports this contention. It is predicted that in the not-to-distant future, supplemental ascorbate will attain an established place in all comprehensive cancer treatment regimes.
每位癌症患者的病情发展在很大程度上取决于个体患者对其疾病的内在抵抗力。人们越来越认识到，对癌症的抵抗力在一定程度上取决于某些营养因素的可获得性，其中抗坏血酸似乎是最重要的。抗坏血酸通过稳定基质和增强胶原包封来防止恶性侵袭的破坏作用。它还参与细胞介导免疫和体液免疫机制，包括干扰素的产生，以及其他已知或被认为共同参与宿主对肿瘤形成抵抗力的因素。最近也有一些证据表明，抗坏血酸盐对恶性细胞具有选择性细胞毒性作用。所有这些观察结果表明，补充抗坏血酸盐在癌症治疗中应具有一定的治疗价值。对过去十年进行的临床试验进行了简要回顾，证据的平衡支持这一观点。预计在不久的将来，补充抗坏血酸盐将在所有综合癌症治疗方案中占据一席之地。
