Veren D, Boehm F H, Killam A P
J Reprod Med. 1982 Jul;27(7):411-4.
A prospective analysis of 34 patients in active labor who were given alphaprodine for analgesia revealed a 32% incidence of sinusoidal fetal heart rate patterns (SFHRP). In a control group of 27 patients who did not receive narcotic analgesia, 1 patient (3.7%) showed a sinusoidal pattern. All study infants, with one exception, who developed SFHRP had a one-minute Apgar score of 7 or greater. Alphaprodine is believed to affect the fetal cardioregulatory center in such a manner as to cause the SFHRP but seems to cause no increase in perinatal morbidity or mortality when given in nontoxic doses.
对34名正在分娩且接受阿法罗定镇痛的产妇进行的前瞻性分析显示，胎儿心率呈正弦波模式（SFHRP）的发生率为32%。在27名未接受麻醉镇痛的对照组产妇中，有1名（3.7%）出现了正弦波模式。除1例例外，所有出现SFHRP的研究婴儿1分钟阿氏评分均为7分或更高。据信，阿法罗定以某种方式影响胎儿心脏调节中心，从而导致SFHRP，但在给予无毒剂量时，似乎不会增加围产期发病率或死亡率。
