Gray J H, Cudmore D W, Luther E R, Martin T R, Gardner A J
Obstet Gynecol. 1978 Dec;52(6):678-81.
Sinusoidal fetal heart rate patterns were observed in 42.5% of a group of 40 women who had received alphaprodine (Nisentil) for relief of labor pain. Analysis showed that the pattern appeared approximately 19 minutes following alphaprodine administration and persisted for approximately 60 minutes. In a control group of 18 patients who did not receive narcotic analgesia, and intermittent sinusoidal pattern was observed in one patient. All babies with sinusoidal heart rate during labor had 1-minute Apgar scores of 7 or greater except two in the study group. Both these neonates had low Apgar scores directly associated with complications at delivery. All 5-minute Apgar scores were 7 or greater, and there were no perinatal deaths.
在一组40名接受阿法罗定（Nisentil）以缓解分娩疼痛的女性中，42.5%观察到正弦型胎儿心率模式。分析表明，该模式在阿法罗定给药后约19分钟出现，并持续约60分钟。在18名未接受麻醉镇痛的对照组患者中，有1名患者观察到间歇性正弦型模式。除研究组中的两名婴儿外，所有在分娩期间出现正弦型心率的婴儿1分钟阿氏评分均为7分或更高。这两名新生儿的阿氏评分均较低，且与分娩时的并发症直接相关。所有5分钟阿氏评分均为7分或更高，且无围产期死亡。
