Miller F C, Mueller E, McCart D
J Reprod Med. 1982 Aug;27(8):439-42.
Alphaprodine is a synthetic narcotic, structurally similar to meperidine. Respiratory depression has been reported as a not-infrequent side effect when larger doses of alphaprodine were used, particularly intravenously. In this study, the maternal respiratory rate and tissue pO2 and pCO2 were determined in patients receiving alphaprodine, 0.4 mg/kg of prepregnancy weight, for first-stage analgesia. Statistically significant falls in maternal tcpO2 and increases in tcpCO2 were observed. The baseline fetal heart rate decreased significantly 20 minutes after the injection (139 to 132 bpm). There was no increase in abnormal fetal heart rate patterns. The variability of the baseline fetal heart rate was unchanged until 25 minutes following alphaprodine administration, when a significant reduction occurred. The changes seen in the parameters monitored in this study were not associated with any clinically adverse effects on the mother or fetus.
阿法罗定是一种合成麻醉剂，在结构上与哌替啶相似。据报道，当使用较大剂量的阿法罗定，尤其是静脉注射时，呼吸抑制是一种并不罕见的副作用。在本研究中，对接受阿法罗定（按孕前体重0.4mg/kg）用于第一产程镇痛的患者，测定了产妇的呼吸频率以及组织氧分压和二氧化碳分压。观察到产妇的经皮氧分压有统计学意义的下降以及经皮二氧化碳分压升高。注射后20分钟，基线胎心率显著下降（从139次/分钟降至132次/分钟）。异常胎心率模式未增加。在阿法罗定给药后25分钟之前，基线胎心率的变异性未变，之后出现显著降低。本研究中监测的参数变化未对母亲或胎儿产生任何临床不良反应。
