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[卵巢癌:标志物、激素受体、免疫状态]

[Ovarian cancer: markers, hormones receptors, immunological status].

作者信息

Martin P M

出版信息

Bull Cancer. 1982;69(3):248-56.

PMID:6181836
Abstract

Like other solid tumors ovarian tumors have been intensely investigated these past years to isolate specific tumoral antigens. These antigens are now used by clinical teams for post therapeutic follow-up. However, out of the 25 major antigens actually described in ovarian carcinomas, the only one that can be used today is the carcinoembryonic antigen (CEA). Moreover, an international collaborative work has demonstrated cross reacting antigenicity between these major tumoral antigens. Cellular enzymes (galactosyl transferase and sialyl-transferase) and hormonal receptors for proteinic hormones such as steroid hormones) are being studied but cannot be used as screening markers at this time.

摘要

与其他实体瘤一样,过去几年对卵巢肿瘤进行了深入研究,以分离特定的肿瘤抗原。目前临床团队将这些抗原用于治疗后的随访。然而,在目前已描述的25种卵巢癌主要抗原中,如今唯一可用的是癌胚抗原(CEA)。此外,一项国际合作研究表明,这些主要肿瘤抗原之间存在交叉反应性抗原。细胞酶(半乳糖基转移酶和唾液酸转移酶)以及蛋白质激素(如类固醇激素)的激素受体正在研究中,但目前尚不能用作筛查标志物。

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