Botez M I, Young S N, Bachevalier J, Gauthier S
J Neurol Neurosurg Psychiatry. 1982 Aug;45(8):731-3. doi: 10.1136/jnnp.45.8.731.
In three out of five patients with low cerebrospinal fluid thiamine concentrations, the 5-hydroxyindoleacetic acid (5HIAA) values also were low. All patients received thiamine replacement therapy; they underwent a second lumbar puncture after 13, 6, 7, 5 and 45 days of treatment. In all patients blood and cerebrospinal fluid thiamine values rose after treatment. In those patients with initially low CSF 5HIAA, thiamine treatment increased 5HIAA markedly.
在脑脊液硫胺素浓度较低的五名患者中，有三名患者的5-羟吲哚乙酸（5HIAA）值也较低。所有患者均接受了硫胺素替代疗法；在治疗13、6、7、5和45天后，他们接受了第二次腰椎穿刺。治疗后，所有患者的血液和脑脊液硫胺素值均升高。在最初脑脊液5HIAA较低的患者中，硫胺素治疗使5HIAA显著增加。
