抗惊厥药诱发的运动障碍：与抗精神病药诱发的运动障碍的比较。
Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics.
作者信息
Chadwick D, Reynolds E H, Marsden C D
出版信息
J Neurol Neurosurg Psychiatry. 1976 Dec;39(12):1210-8. doi: 10.1136/jnnp.39.12.1210.
Abstract
Anticonvulsants cause dyskinesias more commonly than has been appreciated. Diphenylhydantoin (DPH), carbamazepine, primidone, and phenobarbitone may cause asterixis. DPH, but not other anticonvulsants, may cause orofacial dyskinesias, limb chorea, and dystonia in intoxicated patients. These dyskinesias are similar to those caused by neuroleptic drugs and may be related to dopamine antagonistic properties possessed by DPH.
摘要
抗惊厥药引起运动障碍的情况比人们意识到的更为常见。苯妥英钠（DPH）、卡马西平、扑米酮和苯巴比妥可能会导致扑翼样震颤。DPH（而非其他抗惊厥药）可能会在中毒患者中引起口面部运动障碍、肢体舞蹈症和肌张力障碍。这些运动障碍与抗精神病药物引起的运动障碍相似，可能与DPH具有的多巴胺拮抗特性有关。
相似文献
1
Anticonvulsant-induced dyskinesias: a comparison with dyskinesias induced by neuroleptics.抗惊厥药诱发的运动障碍：与抗精神病药诱发的运动障碍的比较。
J Neurol Neurosurg Psychiatry. 1976 Dec;39(12):1210-8. doi: 10.1136/jnnp.39.12.1210.
2
Downbeat nystagmus due to anticonvulsant toxicity.
Ann Neurol. 1978 Nov;4(5):471-3. doi: 10.1002/ana.410040516.
3
The use of blood levels of antiepileptic drugs in clinical practice.抗癫痫药物血药浓度在临床实践中的应用。
Pediatrics. 1974 Apr;53(4):557-60.
4
Schizophrenia-like psychosis associated with anticonvulsant toxicity.
Am J Psychiatry. 1979 Jul;136(7):973-4. doi: 10.1176/ajp.136.7.973.
5
Acute toxicity of antiepileptic drugs.抗癫痫药物的急性毒性
Epilepsia. 1975 Mar;16(1):183-91. doi: 10.1111/j.1528-1157.1975.tb04734.x.
6
Choreo-athetosis and encephalopathy induced by phenytoin.苯妥英钠所致的舞蹈手足徐动症和脑病
Br Med J. 1974 Apr 27;2(5912):204-5. doi: 10.1136/bmj.2.5912.204.
7
Anticonvulsants-induced chorea: a role for pharmacodynamic drug interaction?抗惊厥药物所致舞蹈症：药效学药物相互作用起作用？
Seizure. 2001 Dec;10(8):596-9. doi: 10.1053/seiz.2001.0555.
8
Toxic effects of anticonvulsants: general principles.抗惊厥药的毒性作用：一般原则
Pediatrics. 1974 Apr;53(4):551-7.
9
Bone density in patients receiving long-term anticonvulsant therapy.
Acta Neurol Scand. 1971;47(5):650-1. doi: 10.1111/j.1600-0404.1971.tb07517.x.
10
The toxicity of the major anticonvulsants.主要抗惊厥药的毒性。
Ariz Med. 1978 Mar;35(3):177-9.
引用本文的文献
1
The epidemiology and phenomenology of non-antipsychotic-induced dystonia: a hybrid systematic-narrative review.非抗精神病药物所致肌张力障碍的流行病学与现象学：一项系统-叙述性混合综述
Eur Psychiatry. 2025 Feb 10;68(1):e36. doi: 10.1192/j.eurpsy.2025.18.
2
Phenytoin-associated movement disorder: A literature review.苯妥英钠相关运动障碍：文献综述
Tzu Chi Med J. 2022 Oct 3;34(4):409-417. doi: 10.4103/tcmj.tcmj_74_22. eCollection 2022 Oct-Dec.
3
Movement disorders of the mouth: a review of the common phenomenologies.口腔运动障碍：常见现象学综述。
J Neurol. 2022 Nov;269(11):5812-5830. doi: 10.1007/s00415-022-11299-1. Epub 2022 Jul 29.
4
Movement disorders associated with antiseizure medications: A systematic review.抗癫痫药物相关运动障碍：系统评价。
Epilepsy Behav. 2022 Jun;131(Pt A):108693. doi: 10.1016/j.yebeh.2022.108693. Epub 2022 Apr 25.
5
Prevention of oral and maxillofacial trauma secondary to orofacial dyskinesias associated with anti-N-methyl-D-aspartate receptor encephalitis: a case series.抗 N-甲基-D-天冬氨酸受体脑炎相关口面运动障碍所致口腔颌面外伤的预防：病例系列研究。
BMC Oral Health. 2021 Oct 10;21(1):511. doi: 10.1186/s12903-021-01783-x.
6
Paroxysmal Genetic Movement Disorders and Epilepsy.阵发性遗传性运动障碍与癫痫
Front Neurol. 2021 Mar 23;12:648031. doi: 10.3389/fneur.2021.648031. eCollection 2021.
7
Tardive Dyskinesia-like Syndrome Due to Drugs that do not Block Dopamine Receptors: Rare or Non-existent: Literature Review.非多巴胺受体阻断药物所致的迟发性运动障碍样综合征：罕见或不存在：文献综述
Tremor Other Hyperkinet Mov (N Y). 2018 Aug 31;8:570. doi: 10.7916/D8FF58Z9. eCollection 2018.
8
Medication-Induced Tardive Dyskinesia: A Review and Update.药物性迟发性运动障碍：综述与更新
Ochsner J. 2017 Summer;17(2):162-174.
9
Movement disorders in patients taking anticonvulsants.服用抗惊厥药物患者的运动障碍。
J Neurol Neurosurg Psychiatry. 2007 Feb;78(2):147-51. doi: 10.1136/jnnp.2006.100222. Epub 2006 Sep 29.
10
Dystonia and chorea in acquired systemic disorders.后天性全身性疾病中的肌张力障碍和舞蹈症。
J Neurol Neurosurg Psychiatry. 1998 Oct;65(4):436-45. doi: 10.1136/jnnp.65.4.436.
本文引用的文献
1
STUDIES IN ASTERIXIS. I.扑翼样震颤的研究。一。
Arch Neurol. 1964 Apr;10:360-8. doi: 10.1001/archneur.1964.00460160030002.
2
Quantitative estimation of diphenylhydantoin, primidone and phenobarbital in plasma by gas-liquid chromatography.气液色谱法定量测定血浆中的苯妥英、扑米酮和苯巴比妥。
Clin Chim Acta. 1970 Aug;29(2):282-8. doi: 10.1016/0009-8981(70)90048-3.
3
Receptor activity and turnover of dopamine and noradrenaline after neuroleptics.抗精神病药物治疗后多巴胺和去甲肾上腺素的受体活性及更新率
Eur J Pharmacol. 1970;11(3):303-14. doi: 10.1016/0014-2999(70)90006-3.
4
Pseudodegenerative disease due to diphenylhydantoin intoxication.
Arch Neurol. 1969 Dec;21(6):631-7. doi: 10.1001/archneur.1969.00480180087008.
5
An isothermal GLC determination of the plasma levels of carbamazepine, diphenylhydantoin, phenobarbitone and primidone.卡马西平、苯妥英、苯巴比妥和扑米酮血浆水平的等温气相色谱测定法。
Clin Chim Acta. 1972 May;38(2):321-8. doi: 10.1016/0009-8981(72)90122-2.
6
Abnormal copper and tryptophan metabolism and chelation therapy in anticonvulsant drug intolerance.抗惊厥药物不耐受中的异常铜和色氨酸代谢及螯合疗法。
Dis Nerv Syst. 1966 Feb;27(2):97-107.
7
Movement disorder as a manifestation of diphenylhydantoin intoxication.运动障碍作为苯妥英钠中毒的一种表现形式。
Neurology. 1974 Jan;24(1):68-71. doi: 10.1212/wnl.24.1.68.
8
Role of noradrenaline in levodopa reversal of reserpine akinesia.去甲肾上腺素在左旋多巴逆转利血平引起的运动不能中的作用。
Brain Res. 1974 Sep 13;77(3):521-5. doi: 10.1016/0006-8993(74)90643-x.
9
Acute intoxication with 5,5-diphenylhydantoin (Dilantin) associated with impairment of biotransformation. Plasma levels and urinary metabolites; and studies in healthy volunteers.5,5-二苯基乙内酰脲（苯妥英）急性中毒与生物转化受损相关。血浆水平和尿代谢产物；以及在健康志愿者中的研究。
Ann Intern Med. 1972 Nov;77(5):765-71. doi: 10.7326/0003-4819-77-5-765.
10
Catalepsy and circling behaviour after intracerebral injections of neuroleptic, cholinergic and anticholinergic agents into the caudate-putamen, globus pallidus and substantia nigra of rat brain.向大鼠脑的尾状核-壳核、苍白球和黑质内注射抗精神病药、胆碱能和抗胆碱能药物后出现的僵住症和转圈行为。
Neuropharmacology. 1972 Sep;11(5):645-63. doi: 10.1016/0028-3908(72)90073-1.
Zotero 插件