13 品系豚鼠的慢性复发性实验性变应性脑脊髓炎；免疫后很长时间局部组织中存在髓鞘碱性蛋白。
Chronic relapsing experimental allergic encephalomyelitis in strain 13 guinea pigs; presence of myelin basic protein in the local tissue long after the immunization.
作者信息
Tabira T, Itoyama Y, Kuroiwa Y
出版信息
Jpn J Exp Med. 1982 Jun;52(3):131-7.
In order to obtain a clue to understand the induction mechanism of chronic form of EAE we studied the immunized site of EAE animals with immunocytochemical techniques. There were numerous vacuoles associated with inflammatory reactions in the subcutaneous tissue of immunized feet. Immunocytochemical staining with antiserum to myelin basic protein (MBP) disclosed remaining of MBP in and around the vacuoles. The MBP remained more in early stage and less in chronic stage; it remained even on 326th day of postimmunization. A possible role of the remained antigen in chronic EAE was discussed.
为了获得理解慢性实验性自身免疫性脑脊髓炎（EAE）诱导机制的线索，我们运用免疫细胞化学技术研究了EAE动物的免疫部位。在免疫足部的皮下组织中，存在许多与炎症反应相关的空泡。用抗髓鞘碱性蛋白（MBP）抗血清进行免疫细胞化学染色显示，空泡内及周围有MBP残留。MBP在早期残留较多，在慢性期残留较少；在免疫后第326天仍有残留。文中讨论了残留抗原在慢性EAE中的可能作用。
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