Barrowman J A, Perry M A, Kvietys P R, Granger D N
Am J Physiol. 1982 Nov;243(5):G410-4. doi: 10.1152/ajpgi.1982.243.5.G410.
Measurements were made of hepatic interstitial fluid volume and the proportion of that space occupied by 125I-labeled lactoglobulin, albumin, and gamma-globulin in anesthetized cats. 51Cr-red blood cells and 99mTc-diethylenetriaminepentaacetic acid were used to estimate tissue blood volume and extracellular volume, respectively. Hepatic lymph was assumed to represent the interstitial fluid of the liver. The degree of exclusion of each protein increased with increasing molecular size. At normal hepatic venous pressures, the excluded volume fraction for cat albumin was 0.41. Elevation of hepatic venous pressure by 12.5 mmHg caused a fourfold increase in hepatic lymph flow with an increase in interstitial volume and a reduction in albumin exclusion. When the exclusion of heterologous (human) albumin was studied in the cat liver, much higher values were obtained than with homologous albumin. This effect may be due to polymerization of commercial human albumin on storage.
对麻醉猫的肝间质液体积以及125I标记的乳球蛋白、白蛋白和γ球蛋白在该空间中所占比例进行了测量。分别使用51Cr标记的红细胞和99mTc-二乙三胺五乙酸来估计组织血容量和细胞外液体积。肝淋巴被认为代表肝脏的间质液。每种蛋白质的排阻程度随分子大小增加而增加。在正常肝静脉压力下，猫白蛋白的排阻体积分数为0.41。肝静脉压力升高12.5 mmHg会导致肝淋巴流量增加四倍，同时间质体积增加，白蛋白排阻减少。当在猫肝脏中研究异种（人）白蛋白的排阻时，获得的值比同源白蛋白高得多。这种效应可能是由于市售人白蛋白在储存时发生了聚合。
