间质基质在肠道容积吸收过程中的作用。

Role of the interstitial matrix during intestinal volume absorption.

作者信息

Granger D N, Mortillaro N A, Kvietys P R, Rutili G, Parker J C, Taylor A E

出版信息

Am J Physiol. 1980 Mar;238(3):G183-9. doi: 10.1152/ajpgi.1980.238.3.G183.

DOI:10.1152/ajpgi.1980.238.3.G183

Abstract

The effects of net volume absorption rate (Jv,m) on intestinal interstitial fluid volume (VI), lymph flow (JL), and the excluded volume fraction for interstitial albumin (FE) were analyzed in an autoperfused cat ileum preparation. Tissue blood volume, extracellular space, and extracellular albumin (VA) were estimated using 51Cr-labeled red blood cells, 99mTc-labeled diethylenetriamine pentaacetic acid (DTPA), and 125I-labeled human serum albumin, respectively. Nonabsorptive values of 27.8 ml/100 g, 18.2 ml/100 g, and 0.37 were acquired for VI, VA, and FE, respectively. Net volume absorption results in an increase in intestinal interstitial volume and lymph flow and decreases the degree of albumin exclusion in the interstitial matrix. The magnitude of the changes in interstitial volume, lymph flow, and excluded volume of albumin during net volume absorption are related to the rate of absorption. The increased matrix hydration during absorption serves to enchance vascular and lymphatic removal of absorbed volume.

摘要

在自体灌注猫回肠制备中，分析了净容积吸收率（Jv,m）对肠间质液体积（VI）、淋巴流量（JL）和间质白蛋白排除体积分数（FE）的影响。分别使用51Cr标记的红细胞、99mTc标记的二乙三胺五乙酸（DTPA）和125I标记的人血清白蛋白来估计组织血容量、细胞外间隙和细胞外白蛋白（VA）。VI、VA和FE的非吸收值分别为27.8 ml/100 g、18.2 ml/100 g和0.37。净容积吸收导致肠间质体积和淋巴流量增加，并降低间质基质中白蛋白的排除程度。净容积吸收期间间质体积、淋巴流量和白蛋白排除体积的变化幅度与吸收率有关。吸收过程中基质水合作用的增加有助于增强血管和淋巴管对吸收容积的清除。