Paul S, Jailkhani B L
Am J Reprod Immunol (1980). 1982 Aug;2(4):204-7. doi: 10.1111/j.1600-0897.1982.tb00166.x.
51chromium-labeled syncytiotrophoblasts purified from human placentae were lysed by allogenic leukocytes in vitro. The extent of syncytiotrophoblast lysis was dependent upon the dose of the leukocytes, occurred after a lag period of 42 h, and was inhibited by excess of unlabeled syncytiotrophoblasts. Autologous leukocytes failed to lyse syncytiotrophoblasts. Neuraminidase pretreatment of the syncytiotrophoblasts significantly enhanced their lysis by leukocytes. HCG failed to influence the extent of lysis of untreated syncytiotrophoblasts but significantly reduced the lysis of neuraminidase-treated targets. The significance of these observations in relation to the "immunologic privilege" of the trophoblast in vivo is discussed. (Am J Reprod Immunol. 1982; 204-207.)
从人胎盘中纯化的51铬标记的合体滋养层细胞在体外被同种异体白细胞裂解。合体滋养层细胞的裂解程度取决于白细胞的剂量，在42小时的延迟期后发生，并且被过量的未标记合体滋养层细胞所抑制。自体白细胞不能裂解合体滋养层细胞。对合体滋养层细胞进行神经氨酸酶预处理可显著增强白细胞对其的裂解作用。人绒毛膜促性腺激素未能影响未处理的合体滋养层细胞的裂解程度，但显著降低了神经氨酸酶处理的靶细胞的裂解。讨论了这些观察结果与体内滋养层“免疫特权”的关系。（《美国生殖免疫学杂志》。1982年；204 - 207页。）
