Hendolin H, Penttilä I M
Ann Clin Res. 1982 Feb;14(1):1-6.
In 38 patients subjected to retropubic prostatectomy the effects of continuous lumbar epidural analgesia for 24 hours and the thiopentone- oxygen-nitrous oxide- alcuronium-pethidine sequence with artificial ventilation on the serum activities of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), alpha-hydroxybutyrate dehydrogenase (HBD), and alkaline phosphatase (AP) have been studied. Per- and postoperative complications were recorded according to a prearranged plan designed to quantify the peroperative haemorrhage, postoperative deep vein thrombosis, pulmonary, circulatory and infectious complications. ASAT, ALAT and AP in the general group and ALAT in the epidural group showed significant increases on the 5th and 7th postoperative days. There existed no statistically significant difference between the groups. 82% of the patients with documented postoperative complications combined with hypoxaemia showed a pathologic liver enzyme pattern in contrast to 9% of the patients with uneventful postoperative course. It is concluded that the method of anaesthesia did not have an effect on the liver enzymes. Complications combined with postoperative hypoxaemia seemed to be the factors responsible for the increases of liver enzymes.
对38例行耻骨后前列腺切除术的患者，研究了连续24小时腰段硬膜外镇痛以及硫喷妥钠 - 氧气 - 氧化亚氮 - 阿库氯铵 - 哌替啶序贯用药并人工通气对血清天冬氨酸转氨酶（ASAT）、丙氨酸转氨酶（ALAT）、α - 羟丁酸脱氢酶（HBD）和碱性磷酸酶（AP）活性的影响。按照预先制定的计划记录围手术期和术后并发症，该计划旨在量化术中出血、术后深静脉血栓形成、肺部、循环系统和感染性并发症。普通组的ASAT、ALAT和AP以及硬膜外组的ALAT在术后第5天和第7天显著升高。两组之间无统计学显著差异。有记录的术后并发症合并低氧血症的患者中，82%出现病理性肝酶模式，而术后过程平稳的患者中这一比例为9%。结论是麻醉方法对肝酶无影响。术后并发症合并低氧血症似乎是肝酶升高的原因。
