Ertama P M
Arch Int Pharmacodyn Ther. 1978 May;233(1):82-91.
The effect of five neuromuscular blocking agents on histamine levels of various tissues was studied. Blood and tissue samples were taken from male rats previously treated intravenously with neuromuscular blocking agents. d-Tubocurarine proved to be the most potent histamine liberator. Alcuronium, gallamine and succinylcholine were only moderate histamine liberators, whereas pancuronium released practically no histamine. The results from the individual tissues suggest that the possible sources of increased blood histamine concentrations are tongue and skin with high histamine content. No release of histamine was found from the lung.
研究了五种神经肌肉阻滞剂对各种组织组胺水平的影响。从先前经静脉注射神经肌肉阻滞剂处理的雄性大鼠采集血液和组织样本。结果表明，d -筒箭毒碱是最有效的组胺释放剂。阿库氯铵、加拉明和琥珀酰胆碱只是中等程度的组胺释放剂，而泮库溴铵几乎不释放组胺。各组织的结果表明，血液组胺浓度升高的可能来源是组胺含量高的舌头和皮肤。未发现肺释放组胺。
