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蓝斑到嗅球和嗅结节的差异投射:一项辣根过氧化物酶研究。

Differential projections from locus coeruleus to olfactory bulb and olfactory tubercle: an HRP study.

作者信息

Guevara-Aguilar R, Solano-Flores L P, Donatti-Albarran O A, Aguilar-Baturoni H U

出版信息

Brain Res Bull. 1982 Jun;8(6):711-9. doi: 10.1016/0361-9230(82)90099-5.

DOI:10.1016/0361-9230(82)90099-5
PMID:6182961
Abstract

The microiontophoretic administration of horseradish peroxidase (HRP) to the olfactory bulb (OB) or olfactory tubercle (OT) in cats and rats yielded similar results in both species. After an OB HRP-injection ipsilateral and contralateral labelled neurons were seen in the piriform cortex, polymorphic layer of OT, magnocellular preoptic region, lateral hypothalamus, ventromedial hypothalamic nucleus and locus coeruleus (LC). In both species more labelled structures were found after an OT HRP-injection than after an OB HRP-injection. The substantia nigra in rats was more abundantly labelled after an OT injection than after an OB one. In cats the dorsal and the ventral raphe were also labelled. In either species, OT HRP-injections resulted in a higher frequency of LC labelled neurons than after OB injections. These results favor the hypothesis that the OT plays an important role as a relay station for efferent inflow from the brain stem en route to the OB.

摘要

对猫和大鼠的嗅球(OB)或嗅结节(OT)进行辣根过氧化物酶(HRP)的微量离子电泳给药,在这两个物种中都产生了相似的结果。在向OB注射HRP后,在梨状皮质、OT的多形层、视前大细胞区、下丘脑外侧区、下丘脑腹内侧核和蓝斑(LC)中观察到同侧和对侧标记的神经元。在这两个物种中,OT注射HRP后发现的标记结构比OB注射HRP后更多。OT注射后大鼠黑质的标记比OB注射后更丰富。在猫中,背侧和腹侧中缝也有标记。在任一物种中,OT注射HRP后LC标记神经元的频率都高于OB注射后。这些结果支持了这样一种假设,即OT作为脑干传出信息流通往OB途中的一个中继站发挥着重要作用。

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