Solano-Flores L P, Aguilar-Baturoni H U, Guevara-Aguilar R
Brain Res Bull. 1980 Jul-Aug;5(4):383-9. doi: 10.1016/s0361-9230(80)80008-6.
Locus coeruleus (LC) influences upon the olfactory tubercle (OT) were studied. Evoked potentials and unit activity recording techniques were used as well as the horseradish peroxidase (HRP) labelling method. A biphasic potential was recorded in cat's OT following a single pulse delivered to the LC. Latencies were 35 msec and 80 msec for the first positive and second negative component respectively. The largest potentials were recorded between the superficial part of the pyramidal layer and the polymorphic layer. This potential was tested in order to determine whether it was an OT generated potential caused by LC stimulation. Contralateral recordings were made. Extracellularly recorded OT neurons decreased their discharge frequency upon repetitive LC stimulation in rats. The decreases endured longer when the stimulus frequency or train duration were increased. Neurons from which unit data were used in the analysis were verified to be in the OT polymorphic layer. Labelled neurons were seen in the LC after HRP application to the OT in rats and cats. Results support the presence of LC fibers which influence OT neurons. The relation between the LC as a general arousal system and the OT as an important olfactory information processing structure is discussed.
研究了蓝斑（LC）对嗅结节（OT）的影响。采用了诱发电位和单位活动记录技术以及辣根过氧化物酶（HRP）标记法。向猫的LC施加单个脉冲后，在其OT中记录到一个双相电位。第一个正向成分和第二个负向成分的潜伏期分别为35毫秒和80毫秒。最大电位记录于锥体细胞层浅层和多形层之间。对该电位进行测试以确定它是否为由LC刺激引起的OT产生的电位。进行了对侧记录。在大鼠中，重复刺激LC时，细胞外记录的OT神经元放电频率降低。当刺激频率或串刺激持续时间增加时，这种降低持续的时间更长。用于分析单位数据的神经元经证实位于OT多形层。在大鼠和猫中，将HRP应用于OT后，在LC中可见标记的神经元。结果支持存在影响OT神经元的LC纤维。讨论了作为一般觉醒系统的LC与作为重要嗅觉信息处理结构的OT之间的关系。
