嗅探嗅球对嗅觉的贡献：快感、感觉整合，以及更多？
Sniffing out the contributions of the olfactory tubercle to the sense of smell: hedonics, sensory integration, and more?
机构信息
Emotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
出版信息
Neurosci Biobehav Rev. 2011 Jan;35(3):655-68. doi: 10.1016/j.neubiorev.2010.08.004. Epub 2010 Aug 26.
Abstract
Since its designation in 1896 as a putative olfactory structure, the olfactory tubercle has received little attention in terms of elucidating its role in the processing and perception of odors. Instead, research on the olfactory tubercle has mostly focused on its relationship with the reward system. Here we provide a comprehensive review of research on the olfactory tubercle-with an emphasis on the likely role of this region in olfactory processing and its contributions to perception. Further, we propose several testable hypotheses regarding the likely involvement of the olfactory tubercle in both basic (odor detection, discrimination, parallel processing of olfactory information) and higher-order (social odor processing, hedonics, multi-modal integration) functions. Together, the information within this review highlights an understudied yet potentially critical component in central odor processing.
摘要
自 1896 年被指定为一个假定的嗅觉结构以来，嗅结节在阐明其在气味处理和感知中的作用方面几乎没有得到关注。相反，对嗅结节的研究主要集中在它与奖励系统的关系上。在这里，我们提供了一个关于嗅结节的综合研究综述，重点是该区域在嗅觉处理中的可能作用及其对感知的贡献。此外，我们提出了几个关于嗅结节在基本功能（气味检测、辨别、嗅觉信息的并行处理）和更高阶功能（社交气味处理、快感、多模态整合）中可能参与的可测试假设。总的来说，本综述中的信息突出了一个在中枢气味处理中尚未得到充分研究但具有潜在重要性的组成部分。
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本文引用的文献
1
Neurogenesis in the olfactory tubercle and islands of Calleja in the rat.大鼠嗅结节和Calleja岛中的神经发生
Int J Dev Neurosci. 1985;3(2):135-47. doi: 10.1016/0736-5748(85)90004-8.
2
Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression.急性重度抑郁症患者嗅球体积减小和嗅觉敏感性降低。
Neuroscience. 2010 Aug 11;169(1):415-21. doi: 10.1016/j.neuroscience.2010.05.012. Epub 2010 May 13.
3
Smelling sounds: olfactory-auditory sensory convergence in the olfactory tubercle.嗅觉与听觉的感觉融合：嗅结节中的嗅觉-听觉感觉汇聚。
J Neurosci. 2010 Feb 24;30(8):3013-21. doi: 10.1523/JNEUROSCI.6003-09.2010.
4
Serotonin modulates glutamatergic transmission in the rat olfactory tubercle.5-羟色胺调节大鼠嗅结节中的谷氨酸能传递。
Eur J Neurosci. 2010 Feb;31(4):659-72. doi: 10.1111/j.1460-9568.2010.07084.x. Epub 2010 Feb 5.
5
Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.安非他命给药至腹侧纹状体促进大鼠与非条件视觉信号的行为相互作用。
PLoS One. 2010 Jan 15;5(1):e8741. doi: 10.1371/journal.pone.0008741.
6
Olfactory function and schizophrenia: an update.嗅觉功能与精神分裂症：最新研究进展。
Curr Opin Psychiatry. 2010 Mar;23(2):97-102. doi: 10.1097/YCO.0b013e328336643f.
7
From the top down: flexible reading of a fragmented odor map.自上而下：对碎片化气味图谱的灵活解读。
Trends Neurosci. 2009 Oct;32(10):525-31. doi: 10.1016/j.tins.2009.06.001. Epub 2009 Sep 14.
8
The way an odor is experienced during aversive conditioning determines the extent of the network recruited during retrieval: a multisite electrophysiological study in rats.在厌恶条件反射过程中气味的体验方式决定了在检索过程中所募集的神经网络的范围：一项对大鼠的多部位电生理研究。
J Neurosci. 2009 Aug 19;29(33):10287-98. doi: 10.1523/JNEUROSCI.0505-09.2009.
9
Olfaction in aging and Alzheimer's disease: event-related potentials to a cross-modal odor-recognition memory task discriminate ApoE epsilon4+ and ApoE epsilon 4- individuals.衰老与阿尔茨海默病中的嗅觉：跨模态气味识别记忆任务的事件相关电位可区分载脂蛋白Eε4+和载脂蛋白Eε4-个体。
Ann N Y Acad Sci. 2009 Jul;1170:647-57. doi: 10.1111/j.1749-6632.2009.04486.x.
10
Odor quality coding and categorization in human posterior piriform cortex.人类梨状后皮质中的气味质量编码与分类
Nat Neurosci. 2009 Jul;12(7):932-8. doi: 10.1038/nn.2324. Epub 2009 May 31.
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