Gwynn C M, Almosawi T, Stanworth D R
Clin Allergy. 1982 Sep;12(5):459-64. doi: 10.1111/j.1365-2222.1982.tb01644.x.
Serum total and allergen-specific IgE and IgG4 antibodies, were measured in eighty-seven atopic and nineteen non-atopic asthmatics. The allergens studied were: Dermatophagoides pteronyssinus, grass pollens, cat dander, dog dander, milk and egg. Sixty-eight atopic asthmatics and fourteen non-atopic asthmatics were found to have allergen-specific IgG4 antibodies, to at least one of the allergens tested. IgG4 antibodies to milk and egg were common in both groups of asthmatics, and to animal danders in the non-atopic asthmatics. Skin prick tests were always negative when allergen-specific IgG4 antibodies occurred alone, but in such cases, intradermal skin tests were positive. Seventy-five per cent of a group of patients with normal levels of serum total IgG4, were found to have at least one positive IgG4 RAST.
对87名特应性哮喘患者和19名非特应性哮喘患者检测了血清总免疫球蛋白E（IgE）、变应原特异性IgE和IgG4抗体。所研究的变应原包括：屋尘螨、草花粉、猫毛屑、狗毛屑、牛奶和鸡蛋。结果发现，68名特应性哮喘患者和14名非特应性哮喘患者针对至少一种检测变应原产生了变应原特异性IgG4抗体。两组哮喘患者中针对牛奶和鸡蛋的IgG4抗体均较为常见，非特应性哮喘患者中针对动物毛屑的IgG4抗体也较为常见。当单独出现变应原特异性IgG4抗体时，皮肤点刺试验总是阴性，但在此类情况下，皮内皮肤试验呈阳性。在一组血清总IgG4水平正常的患者中，75%的患者至少有一项IgG4放射性变应原吸附试验（RAST）呈阳性。
