Rode J, Dhillon A P, Papadaki L
Diagn Histopathol. 1982 Jul-Sep;5(3):205-11.
Eight cases of benign granular cell tumour of tongue and skin all showed immunohistochemical staining for neurone specific enolase (NSE). Four Schwannomas, two neurofibromas and Schwann cells of nerves related to these tumours and the granular cell tumours showed no staining for NSE. NSE is a marker for neuronal type cells of the nervous system and cells of the neuroendocrine system. The results support a neural derivation of granular cell tumours. The histogenetic precursor may be an undifferentiated spindle-shaped 'reserve' cell of peripheral nerve, perhaps necessary for replacement of shed sensory organs.
8例舌部和皮肤良性颗粒细胞瘤均显示神经元特异性烯醇化酶（NSE）免疫组化染色阳性。4例神经鞘瘤、2例神经纤维瘤以及与这些肿瘤相关的神经的施万细胞和颗粒细胞瘤均未显示NSE染色。NSE是神经系统神经元型细胞和神经内分泌系统细胞的标志物。这些结果支持颗粒细胞瘤起源于神经。组织发生学上的前体可能是外周神经未分化的梭形“储备”细胞，可能是替代脱落感觉器官所必需的。
