[Effectiveness of intravenous gammaglobulin preparations: comparison between Sandoglobulin and gamma-Venin in the prevention of rubella infections].

Either 5 g Sandoglobulin or 5 g Gamma-Venin was administered in short-time intravenous infusions to 14 volunteers. The gamma-globulin preparation was given to some of the volunteers 24 hours after rubella vaccination, in the others 14 days, in three of the Sandoglobulin group 28 days before rubella vaccination. Gamma-Venin in these circumstances did not retard the vaccination-induced rubella infection. In all volunteers the usual rubella titres developed after the vaccination. Sandoglobulin, on the other hand, in all the given conditions either completely inhibited or at least decreased the rubella infection, an effect which is well known from the experimental studies with standard globulin preparations under administration of similar amounts of antibodies.