Rossier E, Phipps P H, Polley J R, Webb T
Can Med Assoc J. 1977 Mar 5;116(5):481-4.
The long-term effectiveness of rubella vaccination in childhood is particularly important because the ultimate goal of immunization is the prevention of infection during pregnancy. Of 25 healthy children tested 4 to 5 years after rubella vaccination, 19 showed no evidence of cell-mediated immunity (CM) to rubella virus despite the presence of hemagglutination-inhibition or complement-fixation antibodies or both. Twenty-two of 25 seropositive, naturally infected young adults showed evidence of CMI. These results indicate that fetuses of women who have been vaccinated against rubella may not be protected against damage by wild rubella infection during the pregnancy, when CMI is physiologically depressed.
儿童时期风疹疫苗接种的长期有效性尤为重要，因为免疫接种的最终目标是预防孕期感染。在25名风疹疫苗接种4至5年后接受检测的健康儿童中，19名尽管存在血凝抑制或补体结合抗体或两者皆有，但未显示出对风疹病毒的细胞介导免疫（CM）证据。25名血清反应阳性的自然感染年轻成年人中有22名显示出CMI证据。这些结果表明，接种风疹疫苗的女性胎儿在孕期CMI生理上受到抑制时，可能无法免受野生风疹感染的损害。
