[Effect of the endolymphatic administration of protease inhibitors on pancreatic morphofunctional activity in acute experimental pancreatitis].

Experimental acute pancreatitis was induced in 16 dogs by administering infected bile under pressure. Functional and electron microscopic changes in the pancreas were studied before and after endolymphatic infusions of contrykal in a dose of 10 000 ATpE. It was established that endolymphatic administration of contrykal leads to an appreciable decrease in proteolytic activity of the pancreas and to inactivation of the kallikrein-kinin system. Electron microscopy studies of the exocrine apparatus of the pancreas after the dogs' death have demonstrated that endolymphatic administration of contrykal reduces intracellular processes of the synthesis of pancreatic enzymes.