Sejnowski T J
Fed Proc. 1982 Nov;41(13):2923-8.
Biologically active peptides have been localized in neuronal cell bodies, axons, and synaptic boutons of sympathetic ganglia; some of these peptides may be neurotransmitters. For example, substances immunologically similar to substance P and luteinizing hormone-releasing hormone appear to be released from nerve terminals in sympathetic ganglia. In each case, the postsynaptic action of the peptide lasts for several minutes and is accompanied by a combination of decreases and increases in the membrane conductance that are voltage dependent. These peripheral peptidergic synapses may be models for peptidergic transmission in the central nervous system where detailed analysis is more difficult.
生物活性肽已定位在交感神经节的神经元细胞体、轴突和突触小体中；其中一些肽可能是神经递质。例如，与P物质和促黄体生成素释放激素在免疫学上相似的物质似乎是从交感神经节的神经末梢释放出来的。在每种情况下，肽的突触后作用持续几分钟，并伴随着膜电导的降低和增加的组合，这些变化取决于电压。这些外周肽能突触可能是中枢神经系统中肽能传递的模型，在中枢神经系统中进行详细分析更为困难。
