Schulz U, Zoeller M, Matzku S
Chir Forum Exp Klin Forsch. 1977 Apr:63-8.
The leukocyte migration assay proved to be a very sensitive tool in gastric cancer diagnosis. When patients' leukocytes were exposed to a panel of 3m KCl extracts, positive reactivity was found at a rate of 92%. All patients with non-malignant gastric diseases exhibiting "positive" reactivity with gastric tumor extracts also showed a pathological migration index with a 3m KCl extract of normal gastric mucosa, while only in 16% of patients with gastric cancer leukocyte migration was influenced by this extract. Using gastric tumor extracts patients with colorectal cancer showed a cross-reactivity in 67% and patients with carcinoma of the pancreas and oesophagus in 42% of the tests. Three months after curative surgery most patients' leukocyte migration was found to be in the normal range. Positive reactivity reappeared in patients with local recurrence or metastases.
白细胞迁移试验被证明是胃癌诊断中一种非常敏感的工具。当患者的白细胞暴露于一组3m KCl提取物时，阳性反应率为92%。所有对胃肿瘤提取物表现出“阳性”反应的非恶性胃病患者，其正常胃黏膜3m KCl提取物的病理迁移指数也呈阳性，而只有16%的胃癌患者白细胞迁移受该提取物影响。使用胃肿瘤提取物时，结直肠癌患者在67%的测试中出现交叉反应，胰腺癌和食管癌患者在42%的测试中出现交叉反应。根治性手术后三个月，大多数患者的白细胞迁移被发现处于正常范围。局部复发或转移患者再次出现阳性反应。
