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干扰素敏感或耐药淋巴细胞中2'-5'寡腺苷酸合成酶水平。

2'-5' oligo(A) synthetase levels in interferon-sensitive or -resistant lymphoid cells.

作者信息

Koliais S I, Kortsaris A

出版信息

J Gen Virol. 1982 Jan;58 Pt 1:191-3. doi: 10.1099/0022-1317-58-1-191.

DOI:10.1099/0022-1317-58-1-191
PMID:6183394
Abstract

The activity of 2'-5' oligo(A) synthetase has been measured both in control and interferon-treated lymphoid cells. While control or interferon-treated Raji and Namalwa cells exhibit low activity of the 2'-5' oligo(A) synthetase, the activity of this enzyme is increased 20-fold when Daudi cells are treated with the same dose of human interferon. The same enzyme is induced by interferon in R3HR-1 cells to a lesser extent.

摘要

已在对照和经干扰素处理的淋巴细胞中测量了2'-5'寡腺苷酸合成酶的活性。对照或经干扰素处理的拉吉细胞和纳马瓦细胞的2'-5'寡腺苷酸合成酶活性较低，而当用相同剂量的人干扰素处理道迪细胞时，该酶的活性增加了20倍。在R3HR-1细胞中，干扰素对同一种酶的诱导程度较小。

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