Agren H, Oreland L
Psychiatry Res. 1982 Oct;7(2):245-54. doi: 10.1016/0165-1781(92)90097-m.
Platelet monoamine oxidase (MAO) activity was analyzed in 51 patients with Major Depressive Disorder. The enzyme activity was correlated univariately and multivariately using split-half techniques with affective subdiagnosis, sex, body measures, and a great many depressive symptoms. The results indicate that unipolarly depressed patients with higher levels of platelet MAO activity woke up earlier in the morning than they had before becoming depressed. Waking up early appeared to be one least common denominator behind higher MAO activities and a unipolar subdiagnosis. Earlier reports on univariately significant differences in MAO activity between affective subdiagnoses or between the sexes were not replicated. Positive trend correlations were found between homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid and platelet MAO activity. Urinary free cortisol correlated significantly with platelet MAO activity, but only in unipolars.
对51名重度抑郁症患者的血小板单胺氧化酶（MAO）活性进行了分析。采用分半技术，将酶活性与情感亚型诊断、性别、身体测量指标以及大量抑郁症状进行单变量和多变量关联分析。结果表明，血小板MAO活性较高的单相抑郁症患者早晨醒来的时间比抑郁发作前更早。早醒似乎是MAO活性较高和单相亚型诊断背后的一个最不常见的共同特征。之前关于情感亚型诊断之间或性别之间MAO活性存在单变量显著差异的报道未得到重复验证。脑脊液中高香草酸和5-羟吲哚乙酸与血小板MAO活性之间存在正趋势相关性。尿游离皮质醇与血小板MAO活性显著相关，但仅在单相抑郁症患者中如此。
