Amagai T, Nakano K, Cinader B
Scand J Immunol. 1982 Sep;16(3):217-31. doi: 10.1111/j.1365-3083.1982.tb00717.x.
The plaque-forming antibody response of C57BL/6 mice to rabbit gamma globulin (RGG) decreases as a function of ae. RGG in tolerogenic form induces tolerance of young mice but sensitizes older animals. If antigen is administered together with lipopolysaccharide, the age-dependent decline in immune responsiveness is not observed, nor are older animals sensitized by tolerogen. The age-dependent decline in immune responsiveness is due to a loss of T helper capacity; sensitization by tolerogen is attributable to a subpopulation of B cells which becomes sensitized by the tolerogen. Older animals, treated with tolerogen, show a degree of central tolerance of T cells and a relatively slight, age-dependent diminution in colchicine- or cyclophosphamide-sensitive precursors of suppressor cells.
C57BL/6小鼠对兔γ球蛋白（RGG）的噬斑形成抗体反应随年龄增长而降低。致耐受性形式的RGG可诱导幼鼠产生耐受性，但使老年动物致敏。如果抗原与脂多糖一起给予，则不会观察到免疫反应性的年龄依赖性下降，老年动物也不会被致耐受原致敏。免疫反应性的年龄依赖性下降是由于T辅助细胞功能丧失；致耐受原致敏归因于一群被致耐受原致敏的B细胞。用致耐受原处理的老年动物表现出一定程度的T细胞中枢耐受性，以及秋水仙碱或环磷酰胺敏感的抑制细胞前体相对轻微的、年龄依赖性减少。
