Kazandjian S, Fiessinger J N, Camilleri J P, Dadoune J P, Housset E
Acta Derm Venereol. 1982;62(5):425-9.
The labelling index of endothelial cells of the dermal microvessels was studied by in vitro autoradiography with [3H] thymidine. 14 patients with PSS were compared with 7 control subjects, by sampling the upper-third of the forearm skin. One patient had a second biopsy in this area, on a telangiectasis. Microvessels from patients showed a significant increase in endothelial cell labelling. Within the PSS group, no difference was found between the indurated and the non-indurated skin. There was no correlation between the labelling index and the duration of the disease. A very high uptake was found in the telangiectasis. Such an increased labelling index in PSS is consistent with a response to the endothelial cell destruction as described in electron microscopy and in cultures with patient's serum.
采用[3H]胸腺嘧啶核苷体外放射自显影法研究真皮微血管内皮细胞的标记指数。以前臂上1/3皮肤取样，将14例进行性系统性硬化症（PSS）患者与7名对照者进行比较。1例患者在该区域的一处毛细血管扩张部位进行了第二次活检。患者的微血管内皮细胞标记显著增加。在PSS组内，硬结皮肤和非硬结皮肤之间未发现差异。标记指数与疾病持续时间之间无相关性。在毛细血管扩张部位发现摄取非常高。PSS中这种增加的标记指数与电子显微镜及患者血清培养中所描述的内皮细胞破坏反应一致。
