Mécs I, Koltai M
Acta Virol. 1982 Sep;26(5):346-52.
Sendai and Semliki Forest viruses (SFV) raised the interferon (IFN) level in blood and suppressed the acute inflammatory response induced by carrageenan in CFLP mice. After Sendai virus had been inoculated, unresponsiveness developed to repeated challenge either with the same virus or with SFV. The hyporeactive state culminated 48 hr after first virus inoculation. It was characterized (1) by absence of IFN induction and (2) by disappearance of the virus-induced anti-inflammatory effect. In contrast, the anti-inflammatory effect of indomethacin and dexamethasone remained unchanged. In addition, peripheral white blood cells were counted upon Sendai virus inoculation either in normal or in hyporesponsive mice. Six hr after inoculation, Sendai virus induced a marked granulocytosis with lymphopenia. In hyporesponsive mice leukocytosis was observed. Repeated Sendai virus injection was followed by a less pronounced granulocytosis, while the decreased number of mononuclear cells remained unchanged. These alterations in mice inoculated with Sendai virus offers a model of hyporesponsiveness established in vivo.
仙台病毒和Semliki森林病毒（SFV）可提高CFLP小鼠血液中的干扰素（IFN）水平，并抑制角叉菜胶诱导的急性炎症反应。接种仙台病毒后，对相同病毒或SFV的重复攻击会产生无反应性。低反应状态在首次接种病毒后48小时达到顶峰。其特征为：（1）缺乏IFN诱导；（2）病毒诱导的抗炎作用消失。相比之下，吲哚美辛和地塞米松的抗炎作用保持不变。此外，对接种仙台病毒的正常或低反应小鼠的外周血白细胞进行计数。接种后6小时，仙台病毒诱导明显的粒细胞增多伴淋巴细胞减少。在低反应小鼠中观察到白细胞增多。重复注射仙台病毒后，粒细胞增多不太明显，而单核细胞数量减少保持不变。接种仙台病毒的小鼠中的这些变化提供了一种在体内建立的低反应性模型。
