Stein B S, Vangore S, Petersen R O, Kendall A R
Am J Surg Pathol. 1982 Sep;6(6):553-7. doi: 10.1097/00000478-198209000-00007.
In instances of metastatic tumor from an unknown primary site, it is important to isolate those cases which are attributable to prostatic carcinoma. Immunoperoxidase localization of human prostate-specific antigen (PSA) would be useful in this regard if it were reliably detectable in prostatic carcinoma. We have studied 15 specimens from 14 patients with carcinoma of the prostate by immunoperoxidase techniques. The presence of PSA correlates with the Gleason grade. All cases of Gleason grade 9 or less demonstrated strong staining for PSA. Of the seven specimens with a Gleason grade 10, only four (57%) demonstrated significant staining, while two were entirely devoid of PSA. PSA is thus useful when it is present, but the absence of PSA in a poorly differentiated tumor of undetermined origin does not unequivocally rule out the possibility of a prostatic carcinoma.
在原发部位不明的转移性肿瘤病例中，鉴别出那些归因于前列腺癌的病例很重要。如果人前列腺特异性抗原（PSA）在前列腺癌中能够可靠检测到，那么免疫过氧化物酶定位法在这方面将很有用。我们用免疫过氧化物酶技术研究了14例前列腺癌患者的15个标本。PSA的存在与 Gleason分级相关。所有Gleason分级为9级或更低的病例PSA染色均强。在7个Gleason分级为10级的标本中，只有4个（57%）显示出明显染色，而2个完全没有PSA。因此，PSA存在时很有用，但在来源不明的低分化肿瘤中PSA缺失并不能明确排除前列腺癌的可能性。
