Papsidero L D, Croghan G A, Asirwatham J, Gaeta J, Abenoza P, Englander L, Valenzuela L
Am J Pathol. 1985 Dec;121(3):451-4.
With the use of a murine monoclonal antibody (F5), a panel of metastatic tumors was evaluated for the expression of prostate-specific antigen (PA) under immunoperoxidase staining procedures. Specimens studied included 25 of prostatic origin and 73 originating from nonprostatic primary sites. Regardless of the site of dissemination or the malignancy grade, all metastases from the prostate were antibody-reactive. In contrast, nonprostatic metastases were negative in each case, including those originating from other genitourinary neoplasms. Thus, PA expression as detected with monoclonal antibody F5 is a stable characteristic of disseminated prostatic tumors.
使用鼠单克隆抗体（F5），在免疫过氧化物酶染色程序下评估一组转移性肿瘤中前列腺特异性抗原（PA）的表达。研究的标本包括25个前列腺来源的和73个非前列腺原发部位来源的。无论转移部位或恶性程度如何，所有前列腺转移灶均与抗体反应。相比之下，非前列腺转移灶在每种情况下均为阴性，包括那些源自其他泌尿生殖系统肿瘤的转移灶。因此，用单克隆抗体F5检测到的PA表达是播散性前列腺肿瘤的一个稳定特征。
