眼内抗病毒药物渗透。
Intraocular antiviral penetration.
作者信息
Poirier R H, Kingham J D, de Miranda P, Annel M
出版信息
Arch Ophthalmol. 1982 Dec;100(12):1964-7. doi: 10.1001/archopht.1982.01030040944016.
Abstract
Aqueous levels of topically applied vidarabine monophosphate, trifluridine, and acyclovir were determined following topical administration in patients with normal corneas prior to cataract extraction. Meager levels in aqueous were found for vidarabine monophosphate, and none for trifluridine. Substantial levels of acyclovir were detected that were well within the therapeutic range of herpes simplex susceptibility.
摘要
在白内障摘除术前，对正常角膜患者进行局部给药后，测定了局部应用的单磷酸阿糖腺苷、三氟尿苷和阿昔洛韦的房水浓度。发现单磷酸阿糖腺苷的房水浓度很低，三氟尿苷则未检测到。检测到阿昔洛韦的浓度较高，且完全在单纯疱疹易感性的治疗范围内。
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