口服阿昔洛韦（无环鸟苷）在眼部的药代动力学。
Pharmacokinetics of oral acyclovir (Zovirax) in the eye.
作者信息
Hung S O, Patterson A, Rees P J
出版信息
Br J Ophthalmol. 1984 Mar;68(3):192-5. doi: 10.1136/bjo.68.3.192.
Abstract
Patients due for cataract extraction received 5 doses of 400 mg acyclovir (Zovirax) orally during the 24 hours prior to surgery. Aqueous humour levels of acyclovir (mean 3.26 microM) were well above the normal ED50 range for herpes simplex virus type 1, and showed a significant correlation with plasma concentrations (mean 8.74 microM). There was also a correlation between the age of the patient and the concentration of acyclovir in the plasma. Oral acyclovir was well tolerated.
摘要
计划接受白内障摘除术的患者在手术前24小时内口服5剂400毫克阿昔洛韦（无环鸟苷）。阿昔洛韦的房水浓度（平均3.26微摩尔）远高于单纯疱疹病毒1型的正常半数有效剂量范围，并且与血浆浓度（平均8.74微摩尔）呈显著相关性。患者年龄与血浆中阿昔洛韦浓度之间也存在相关性。口服阿昔洛韦耐受性良好。
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本文引用的文献
1
Acyclovir and vidarabine for the treatment of herpes simplex keratitis.
Am J Med. 1982 Jul 20;73(1A):281-5. doi: 10.1016/0002-9343(82)90106-1.
2
Acyclovir in severe herpes virus infections.
Am J Med. 1982 Jul 20;73(1A):271-4. doi: 10.1016/0002-9343(82)90104-8.
3
Pharmacokinetics of acyclovir in humans following intravenous administration. A model for the development of parenteral antivirals.
Am J Med. 1982 Jul 20;73(1A):165-71. doi: 10.1016/0002-9343(82)90084-5.
4
Overview of acyclovir pharmacokinetic disposition in adults and children.
Am J Med. 1982 Jul 20;73(1A):186-92. doi: 10.1016/0002-9343(82)90088-2.
5
Comparative trial of acyclovir and adenine arabinoside in the treatment of herpes simplex corneal ulcers.
Br J Ophthalmol. 1981 Sep;65(9):610-3. doi: 10.1136/bjo.65.9.610.
6
[Superficial herpes simplex keratitis. Double-blind comparative trial of acyclovir and idoxuridine (author's transl)].
Nouv Presse Med. 1981 Oct 10;10(36):2969-70, 2975.
7
Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration.
Br J Ophthalmol. 1980 Oct;64(10):766-9. doi: 10.1136/bjo.64.10.766.
8
A comparison of acyclovir and idoxuridine as treatment for ulcerative herpetic keratitis.
Br J Ophthalmol. 1980 Oct;64(10):763-5. doi: 10.1136/bjo.64.10.763.
9
Acyclovir and trifluorothymidine in herpetic keratitis: a multicentre trial.
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10
Acyclovir and idoxiuridine treatment of herpes simplex keratitis--a double blind clinical study.
Acta Ophthalmol (Copenh). 1982 Oct;60(5):838-44. doi: 10.1111/j.1755-3768.1982.tb06748.x.
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