Ward P J, Sanderson A R
Immunology. 1983 Jan;48(1):87-92.
Derivatives of human Beta 2 microglobulin (B2M) have been made by attaching various groups to amino groups in the peptide. In this way iodine, dinitrobenzyl, and m-maleimidobenzoyl groups have been introduced. These derivatives of B2M were able to associate with HLA chains and could be displaced again by native B2M. The rate of dissociation of HLA chains and derivatives of B2M is comparable with the intrinsically labelled native dimer. In some cases, particularly with [I]-B2M, the rate of dissociation appears to be smaller than for native B2M.
人β2微球蛋白（B2M）的衍生物是通过将各种基团连接到肽中的氨基上而制成的。通过这种方式，引入了碘、二硝基苄基和间马来酰亚胺苯甲酰基。这些B2M衍生物能够与HLA链结合，并且可以被天然B2M再次取代。HLA链与B2M衍生物的解离速率与内在标记的天然二聚体相当。在某些情况下，特别是对于[I]-B2M，解离速率似乎比天然B2M小。
