人类β2微球蛋白的犬类同源物。
Dog homologue of human 2 -microglobulin.
作者信息
Smithies O, Poulik M D
出版信息
Proc Natl Acad Sci U S A. 1972 Oct;69(10):2914-7. doi: 10.1073/pnas.69.10.2914.
Abstract
The amino-acid sequence of human beta(2)-microglobulin, a protein of 100 residues, is related to parts of the constant region of IgG heavy chain. The dog homologue of human beta(2)-microglobulin has now been isolated and its amino-acid sequence has been partially determined. The two proteins (human and dog beta(2)-microglobulins) are demonstrably different at only 6 or 7 of the 42 positions examined. Use of the dog should permit experimental investigation of the functional relationships of beta(2)-microglobulin to immunoglobulins and the immune system. beta(2)-Microglobulin has also been detected in serum from a chimpanzee. The gene for beta(2)-microglobulin may correspond to the end portion of an immunoglobulin heavy chain gene.
摘要
人β2-微球蛋白是一种由100个氨基酸残基组成的蛋白质，其氨基酸序列与IgG重链恒定区的部分序列相关。现已分离出犬类与人β2-微球蛋白的同源物，并部分测定了其氨基酸序列。在所检测的42个位置中，这两种蛋白质（人β2-微球蛋白和犬β2-微球蛋白）仅有6或7个位置明显不同。利用犬类可对β2-微球蛋白与免疫球蛋白及免疫系统的功能关系进行实验研究。在黑猩猩的血清中也检测到了β2-微球蛋白。β2-微球蛋白基因可能与免疫球蛋白重链基因的末端部分相对应。
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本文引用的文献
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