Woodrow D, Ronco P, Riviere Y, Moss J, Gresser I, Guillon J C, Morel-Maroger L, Sloper J C, Verroust P
J Pathol. 1982 Dec;138(4):325-36. doi: 10.1002/path.1711380404.
Renal lesions due to neonatal infection with lymphocytic choriomeningitis virus were studied in three different strains of mice known to produce different amounts of viral interferon. Very severe ultrastructural lesions similar to those induced by exogenous interferon were found as early as day 8 in C3H mice which produced the highest amount of interferon. Further studies could not be performed in these mice since all died by day 14. Balb/c mice produced the lowest amount of interferon and had very mild ultrastructural lesions. An intermediate pattern was found in Swiss mice. After 30 days of infection, severe immune complex type glomerulonephritis detectable by light microscopy and immunofluorescence was observed in Swiss mice whereas mild lesions only were found in Balb/c mice. Circulating immune complexes were present in both strains but in greater amounts of Swiss than Balb/c mice. These results suggest that two factors at least are important in the development of glomerulonephritis: interferon produced early in life and the load of circulating immune complexes.
在已知能产生不同量病毒干扰素的三种不同品系小鼠中，研究了新生小鼠感染淋巴细胞性脉络丛脑膜炎病毒所致的肾脏病变。在产生干扰素量最高的C3H小鼠中，早在第8天就发现了与外源性干扰素诱导的病变相似的非常严重的超微结构病变。由于所有这些小鼠在第14天前均死亡，因此无法对其进行进一步研究。Balb/c小鼠产生的干扰素量最低，超微结构病变非常轻微。在瑞士小鼠中发现了一种中间模式。感染30天后，在瑞士小鼠中观察到通过光学显微镜和免疫荧光可检测到的严重免疫复合物型肾小球肾炎，而在Balb/c小鼠中仅发现轻微病变。两种品系小鼠均存在循环免疫复合物，但瑞士小鼠中的循环免疫复合物量多于Balb/c小鼠。这些结果表明，至少有两个因素在肾小球肾炎的发展中很重要：生命早期产生的干扰素和循环免疫复合物的负荷。
