Rivière Y, Gresser I, Guillon J C, Bandu M T, Ronco P, Morel-Maroger L, Verroust P
J Exp Med. 1980 Sep 1;152(3):633-40. doi: 10.1084/jem.152.3.633.
A marked difference was observed in the severity of disease in lymphocytic choriomeningitis (LCM) virus-infected suckling BALB/c, Swiss, and C3H mice. BALB/c mice had minimal liver lesions and none died, whereas C3H mice had extensive liver lesions and all mice died. An intermediate pattern was oberved for Swiss mice (36% mortality). Although there was no difference in the titers of LCM virus in the plasma or liver between these three strains of mice, there was a marked difference in the amount of interferon produced and the duration of interferonemia. C3H mice produced more interferon than Swiss mice which produced more interferon than BALB/c mice, indicating a direct correlation between the amount of interferon induced by LCM virus and the extent of disease. Inoculation of a potent anti-mouse interferon globulin markedly reduced the incidence of mortality in virus-infected C3H mice. BALB/c mice were as sensitive to the effects of interferon as C3H mice because daily administration of potent interferon preparations did induce disease in this strain. This ensemble of results supports our contention that endogenous interferon is in large part responsible for the manifestaions of acute LCM virus disease in suckling mice.
在感染淋巴细胞性脉络丛脑膜炎（LCM）病毒的乳鼠BALB/c、瑞士小鼠和C3H小鼠中，观察到疾病严重程度存在显著差异。BALB/c小鼠肝脏病变轻微，无一死亡，而C3H小鼠肝脏病变广泛，所有小鼠均死亡。瑞士小鼠呈现出中间模式（死亡率为36%）。尽管这三种品系小鼠的血浆或肝脏中LCM病毒滴度没有差异，但产生的干扰素量和干扰素血症持续时间存在显著差异。C3H小鼠产生的干扰素比瑞士小鼠多，而瑞士小鼠产生的干扰素又比BALB/c小鼠多，这表明LCM病毒诱导产生的干扰素量与疾病程度直接相关。接种高效抗小鼠干扰素球蛋白可显著降低病毒感染的C3H小鼠的死亡率。BALB/c小鼠对干扰素的作用与C3H小鼠一样敏感，因为每天给予高效干扰素制剂确实会在该品系小鼠中引发疾病。这一系列结果支持了我们的观点，即内源性干扰素在很大程度上导致了乳鼠急性LCM病毒病的表现。
