干扰素在临床放射治疗中的应用
Utility of interferons in clinical radiotherapy.
作者信息
Mossman K L, Hill L T, Dritschilo A
出版信息
J Natl Med Assoc. 1982 Nov;74(11):1083-7.
Abstract
Interferons are being tested in the treatment of a wide range of malignancies. Clinical experience has indicated that interferons may have relatively few side effects compared to other commonly used antineoplastic agents. In addition, they have shown activity as radiation response modifiers in various experimental systems. Thus, as natural biological compounds, interferons may prove to be superior to other radiation response modifiers now on clinical trial in radiotherapy. In this paper radiation-interferon interactions are reviewed and the evaluation of the usefulness of interferons as an adjuvant in radiotherapy is discussed.
摘要
干扰素正在多种恶性肿瘤的治疗中进行测试。临床经验表明，与其他常用的抗肿瘤药物相比，干扰素的副作用可能相对较少。此外，在各种实验系统中，它们已显示出作为辐射反应调节剂的活性。因此，作为天然生物化合物，干扰素可能被证明优于目前正在放疗临床试验中的其他辐射反应调节剂。本文综述了辐射与干扰素的相互作用，并讨论了干扰素作为放疗辅助剂的效用评估。
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Tumor suppression by a lymphokine released into the circulation of mice with delayed hypersensitivity.通过释放到迟发型超敏反应小鼠循环系统中的一种淋巴因子实现肿瘤抑制。
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