改变对辐射的反应：增敏剂和防护剂。
Altering the response to radiation: sensitizers and protectors.
作者信息
Citrin Deborah E, Mitchell James B
机构信息
Radiation Oncology Branch and Radiation Biology Branch of the National Cancer Institute, Bethesda, MD.
Radiation Oncology Branch and Radiation Biology Branch of the National Cancer Institute, Bethesda, MD.
出版信息
Semin Oncol. 2014 Dec;41(6):848-59. doi: 10.1053/j.seminoncol.2014.09.013. Epub 2014 Oct 7.
Abstract
A number of agents are used clinically to enhance the efficacy of radiotherapy today, many of which are cytotoxic chemotherapies. Agents that enhance radiation induced tumor cell killing or protect normal tissues from the deleterious effects of ionizing radiation are collectively termed radiation modifiers. A significant effort in radiobiological research is geared towards describing and testing radiation modifiers with the intent of enhancing the therapeutic effects of radiation while minimizing normal tissue toxicity. In this review, we discuss the characteristics of these agents, the testing required to translate these agents into clinical trials, and highlight some challenges in these efforts.
摘要
如今，临床上使用多种药物来提高放射治疗的疗效，其中许多是细胞毒性化疗药物。增强辐射诱导的肿瘤细胞杀伤或保护正常组织免受电离辐射有害影响的药物统称为辐射修饰剂。放射生物学研究的一项重要工作致力于描述和测试辐射修饰剂，目的是提高辐射的治疗效果，同时将正常组织毒性降至最低。在这篇综述中，我们讨论了这些药物的特性、将这些药物转化为临床试验所需的测试，并强调了这些努力中的一些挑战。
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